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Two models are available for the quantification of myocardial perfusion PET studies using H215O water bolus injection. They only differ in the way how they handle spill-over correction. The model configuration is a 1-tissue compartment model below.
The distribution of the freely diffusible inert tracer H215O in myocardium can be described by a 1-tissue compartment model
with the myocardial blood flow F and the myocardium to blood partition coefficient of water p.