The estimation of the internal radiation dose is a common requirement for novel radiotracers in nuclear medicine.

PMOD offers a tailored workflow of dosimetry pre-processing steps using the base tool PBAS and the kinetic modeling tool PKIN. The resulting cumulated activities (residence times) form the input into standard programs for the actual dose calculation, such as OLINDA/EXM or IDAC, as exemplified in the publication of Hjornevik et al.

“PMOD provides elegant and effective solutions for the various tasks of PET image and data analysis.”

Dr. Mehdi AdinehAmerican College of Radiology Imaging Network (ACRIN)
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  • Matching of anatomical scans to the dosimetry series.
  • Merging of static into a dynamic series, accounting for differences in decay correction.
  • Definition of organ VOIs using multiple contouring approaches.
  • Support of dynamic VOIs to track organs in follow-up acquisitions.
  • Handling of positional time differences along the axial field-of-view in dynamic whole-body scans.
  • Calculation of organ TACs from dynamic series.
  • Calculation of organ residence times with various integration and extrapolation algorithms.
  • Standard organ naming for smooth interfacing to dose calculation programs.
  • Export of residence times in OLINDA/EXM format.