**Create Synthetic PXMOD Study** is an extension of the **Create Synthetic KM Study** approach. The idea is that synthetic model curves can be generated for many different "tissues", ie. combinations of model parameters, at once. These curves are compiled into images, so that a synthetic study is generated which has a different combination of model parameters in each pixel.

For instance, FDG TACs can be simulated by loading a FDG .km file, selecting the FDG 2- tissue compartment model and using the parameter ranges

Parameter |
From |
To |

K |
0.05 |
0.1 |

k |
0.06 |
0.11 |

k |
0.04 |
0.08 |

k |
fixed to 0.0 |

To enter these parameter ranges select **Create Synthetic PMOD Study** from the **File**. The following dialog appears showing the parameters of the current model.

To define the synthetic study the following configurations must be set:

- Which parameters are varied along the X, Y, and Z axis,
- the value ranges of the varied parameters,
- the number of parameter increments to cover the ranges,
- the acquisition times; initially the times of the loaded .km study are used, but they can be changed using the
**Set time points**.

With **Generate** the model curves of all parameter combinations are generated and the data arranged as a 4-dimensional study. This synthetic study, which is suitable for pixel-wise modeling, is shown in the upper image display. In the example above the interpolation has been disabled to show the 10x10 layout of parameter combinations in plane. Use the **Save Generated** button to save the study in any supported output format.

The lower image display contains the true parameter images. These generation parameters can be saved using the **Save True** button. They will be helpful for the analysis of the outcome from a pixel-wise analysis of the synthetic study.