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Cardiac Flow from Water PET

Two models are available for the quantification of myocardial perfusion PET studies using H215O water bolus injection. They only differ in the way how they handle spill-over correction. The model configuration is a 1-tissue compartment model below.

The distribution of the freely diffusible inert tracer H215O in myocardium can be described by a 1-tissue compartment model

Equation Cardiac Water

with the myocardial blood flow F and the myocardium to blood partition coefficient of water p.