Cardiac Flow from Acetate PET
Van den Hoff et al.  have investigated and validated 11C-acetate as a flow tracer. This methodology is implemented as the Card Acetate (1 Compartment) model. It employs a single tissue compartment model
with tracer exchange between arterial plasma Ca and myocardial tissue Cmyo and a differential equation
A metabolite correction is necessary to derive the plasma activity from whole blood measured in the left cavity.
with T1/2=5.3 min. K1 is the product of flow F and extraction E which is flow dependent for acetate. The relation found  is described by the following relation
Additionally, the model incorporates a cardiac dual spillover correction by the operational equation
Vlv = spill-over fraction of the blood activity in the left ventricle Clv(t),
Vrv = spill-over fraction of the blood activity in the right ventricle Crv(t) .
- The right ventricle curve is only used for spillover correction of septal TACs. It must be loaded as the Total blood curve.
- The left ventricle curve serves two purposes: (1) corrected by the metabolite buildup it serves as the input curve, (2) it is used for spillover correction of all myocardial TACs. It must be loaded as the Input curve.
- The spill-over fraction from the right ventricle Vrv is automatically fixed to zero if the string "Sep" is not contained in the name a region. The assumption is that such a TAC is not from septal tissue and should thus be modeled with spill-over from the left ventricle only. The reason for this automatism is usage of the model in the PCARD tool.
- To set Vrv = 0 in all regional models proceed as follows: in one region, set Vrv =0 and disable the fit checkbox; fit the region; configure the button below Copy to all regions to Model and Par. and activate it.