In PCARDM, left ventricular perfusion is quantified by the following steps:
- Loading of the dynamic perfusion series. Here it is important that the acquisition timing information is correctly interpreted, because otherwise modeling will not provide correct results.
- Interactive cropping of the heart volume from the surrounding tissue.
- Loading of the B1 correction map (COCA) and correction of the perfusion signal (optional).
- Interactive definition of the left ventricle segments in all slices of the left ventricle.
- Interactive definition of a representative blood volume in the center of the left ventricular (LV) cavity.
- Calculation of the average MR signal curves in the LV segments and the LV cavity.
- Loading of the T1 series and geometric interpolation to the perfusion scan (optional).
- Calculation of the average T1 in the LV segments and the cavity.
- Conversion of the signal curves to contrast concentration.
- Optional concentration curve filtering and baseline correction.
- Quantification of the segmental concentration curves by one of the available methods, using the LV cavity contrast concentration as the arterial input function. The result is a segmental perfusion value in [ml/min/g] per segment.
- Calculation of the segmental coronary perfusion reserves.
- Documentation of the outcome in comprehensive reports.
- Saving of all configurations in a protocol so that the data analysis can be exactly reproduced and examined any time later.