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This new tool leverages the PMOD platform for supporting various types of simulations. A model builder allows for the construction of anatomic structures from VOIs, resulting in a geometric model. Such models can be enriched by multimedia annotations for creating educational 3D-scenes, and complemented by tissue properties. Based on the model construct, phantom images can easily be generated which represent a well-defined input for external simulators of image acquisition instruments or physiology, e.g., OpenFOAM® or Fluent®. An alternative output constitutes atlases which can be employed for automatic VOI generation.