**Create Synthetic PXMOD Study** is an extension of the **Create Synthetic KM Study** approach. The idea is that synthetic model curves can be generated for many different "tissues", ie. combinations of model parameters, at once. These curves are compiled into images, so that a synthetic study is generated which has a different combination of model parameters in each pixel.

For instance, TACs can be simulated by loading a .km file, selecting the 2-tissue compartment model and using the parameter ranges

Parameter |
From |
To |

K |
0.05 |
0.1 |

k |
0.05 |
0.25 |

k |
0.02 |
0.04 |

k |
fixed to 0.05 |

To enter these parameter ranges select **Create Synthetic PMXOD Study** from the **File** menu. The following dialog appears showing the parameters of the current model.

To define the synthetic study the following configurations must be set:

- Which parameters are varied along the
**X**,**Y**, and**Z**axis (**Axis**selection), - the value ranges of the varied parameters (
**Start from**,**Finish at**), - the number of parameter increments to cover the ranges (
**X**,**Y**,**Z samples**), - the acquisition times; initially the times of the loaded .km study are used, but they can be changed using the
**Set time points**.

With **Generate** the model curves of all parameter combinations are generated and the data arranged as a 4-dimensional study. This synthetic study, which is suitable for pixel-wise modeling, is shown in the upper image display. In the example above the interpolation has been disabled to show the 10x10 layout of parameter combinations in plane. Use the **Save Synthetic Results** button to save the study in any supported output format.

The lower image display contains the true parameter images. These generation parameters can be saved using the **Save True Results** button. They can serve as the reference for the analysis of the outcome from a pixel-wise analysis of the synthetic study.